2024-03-28T08:22:47Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/225532019-10-01T11:43:38Zcom_10261_133com_10261_1col_10261_386
Simulation of cytoskeleton influence on spatial Ca2+ dynamics in neuroendocrine cells
Gil, Amparo
González-Vélez, Virginia
Segura, Javier
Torregrosa-Hetland, Cristina J.
Villanueva, José
López-Font, Inmaculada
Gutiérrez, Luis M.
2 pages.-- Poster presentation from Eighteenth Annual Computational Neuroscience Meeting: CNS*2009
Berlin, Germany. 18–23 July 2009
The adrenal medulla inside the adrenal glands, which is
situated over the kidneys, is composed of chromaffin
cells. These cells release vital hormones like epinephrine
and norepinephrine in response to stress. Cell depolariza-
tion force calcium channel opening which allows external
calcium to enter inside the cell; this in turn activates vesi-
cles towards release. Once Ca
2+
enters inside the cell, it is
heterogeneously distributed in different zones of the cyto-
plasm and the F-actin cytoskeletal network seems to play
a crucial role in this dynamic behavior [1]. Cytoskeleton
is a dynamic supporting structure inside the cell that
exhibits a very complex 3-D polygonal shape. It forms
walls and empty spaces in the cytosol. In chromaffin cells,
we have found that the highest levels of Ca
2+
are found in
the interior of cytoskeletal cages (empty spaces), whereas
Ca
2+
is low in the cytoskeletal walls. This possibly happens
because this structure is acting as a physical barrier. Since
cytoskeleton is not a static structure, its complex dynamics
would affect the Ca
2+
spatial distribution along time and
finally, it would also has an impact on exocytosis. Moreo-
ver, we have also encountered evidences that calcium
channels are organized in clusters, and that they are posi-
tioned in the border of cytoskeletal cages together with
secretory vesicles. Then, active sites for secretion (where
release occurs) may be placed near empty spaces of
cytoskeletal cages probably to allow efficient exocytosi
2010-03-22T11:50:25Z
2010-03-22T11:50:25Z
2009-07-13
artículo
BMC Neuroscience 10(Suppl. 1):P31(2009)
1471-2202
http://hdl.handle.net/10261/22553
10.1186/1471-2202-10-S1-P31
eng
Publisher’s version
http://dx.doi.org/10.1186/1471-2202-10-S1-P31
openAccess
BioMed Central