2024-03-29T05:11:10Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2222992021-12-27T16:10:29Zcom_10261_22com_10261_1col_10261_275
Nordihydroguaiaretic acid: From herbal medicine to clinical development for cancer and chronic diseases
Manda, Gina
Rojo, Ana I.
Martínez-Klimova, Elena
Pedraza-Chaverri, José
Cuadrado, Antonio
Ministerio de Economía y Competitividad (España)
Fundación Tatiana Pérez de Guzmán el Bueno
Consejo Nacional de Ciencia y Tecnología (México)
Universidad Autónoma Metropolitana (México)
Comunidad de Madrid
European Commission
Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata, the creosote bush found in Mexico and USA deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. NDGA presents two catechol rings that confer a very potent antioxidant activity by scavenging oxygen free radicals and this may explain part of its therapeutic action. Additional effects include inhibition of lipoxygenases (LOXs) and activation of signaling pathways that impinge on the transcription factor Nuclear Factor Erythroid 2-related Factor (NRF2). On the other hand, the oxidation of the catechols to the corresponding quinones my elicit alterations in proteins and DNA that raise safety concerns. This review describes the current knowledge on NDGA, its targets and side effects, and its synthetic analogs as promising therapeutic agents, highlighting their mechanism of action and clinical projection towards therapy of neurodegenerative, liver, and kidney disease, as well as cancer.
2020-11-05T08:32:28Z
2020-11-05T08:32:28Z
2020
artículo
Frontiers in Pharmacology 11: 151 (2020)
http://hdl.handle.net/10261/222299
10.3389/fphar.2020.00151
1663-9812
http://dx.doi.org/10.13039/501100010805
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003141
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100004173
32184727
eng
Publisher's version
https://doi.org/10.3389/fphar.2020.00151
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76520-R
B2017/BMD-3827/NRF24AD-CM
http://creativecommons.org/licenses/by/4.0/
openAccess
Frontiers Media