2024-03-28T12:58:06Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2189902021-12-28T16:09:45Zcom_10261_34com_10261_5com_10261_81col_10261_287col_10261_334
Peptides mimicking the β7/β8 loop of HIV'1 reverse transcriptase p51 as “hotspot-targeted” dimerization inhibitors
Sánchez-Murcia, Pedro A.
Castro, Sonia de
García-Aparicio, Carlos
Jiménez, M. Angeles
Corona, A.
Tramontano, Enzo
Sluis-Cremer, N.
Menéndez-Arias, Luis
Velázquez, Sonsoles
Gago, Federico
Camarasa Rius, María José
Ministerio de Economía y Competitividad (España)
Fundación Ramón Areces
Constrained peptides
Dimerization hotspot
Dimerization inhibitors
HIV reverse transcriptase.
A conformationally constrained short peptide designed to target a protein−protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.
2020-09-02T09:40:07Z
2020-09-02T09:40:07Z
2020
2020-09-02T09:40:08Z
artículo
ACS Medicinal Chemistry Letters 11: 811-817 (2020)
http://hdl.handle.net/10261/218990
10.1021/acsmedchemlett.9b00623
http://dx.doi.org/10.13039/100008054
http://dx.doi.org/10.13039/501100003329
32435389
http://dx.doi.org/10.1021/acsmedchemlett.9b00623
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64629-C2
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2016-76716-R
openAccess
American Chemical Society