2024-03-28T16:58:40Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2126632021-04-05T07:41:44Zcom_10261_11773com_10261_1col_10261_11774
Sociodemographic changes and trends in the rates of new perinatal HIV diagnoses and transmission in Spain from 1997 to 2015
Jiménez de Ory, Santiago
Ramos, José Tomás
Fortuny, Claudia
Gonzalez-Tome, Maria I.
Mellado, Maria Jose
Moreno-Pérez, David
Gavilán, César
Menasalvas, Ana Isabel
Piqueras, Ana I.
Frick, M. Antoinette
Muñoz-Fernández, María Ángeles
Navarro Gómez, María Luisa
Red Española de Investigación en SIDA
Instituto de Salud Carlos III
European Commission
Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo
National Institutes of Health (US)
Wellcome Trust
Howard Hughes Medical Institute
[Background] There are not enough nationwide studies on perinatal HIV transmission in connection with a combination of antiretroviral treatments in Spain. Our objectives were to study sociodemographic changes and trends in the rates of HIV diagnoses and perinatal transmission in Spain from 1997 to 2015.
[Methods] A retrospective study using data from Spanish Paediatric HIV Network (CoRISpe) and Spanish Minimum Basic Data Set (MDBS) was performed. HIV- diagnosed children between 1997 and 2015 were selected. Sociodemographic, clinical and immunovirological data of HIV-infected children and their mothers were studied in four calendar periods (P1: 1997–2000; P2: 2001–2005; P3: 2006–2010; P4: 2011–2015). Rates of perinatal HIV diagnoses and transmission from 1997 to 2015 were calculated.
[Results] A total of 532 HIV-infected children were included in this study. Of these children, 406 were Spanish (76.3%) and 126 immigrants (23.7%). A decrease in the number of HIV diagnoses, 203 (38.2%) children in the first (P1), 149 (28%) in the second (P2), 130 (24.4%) in the third (P3) and 50 (9.4%) in the fourth (P4) calendar periods was studied. The same decrease in the Spanish HIV-infected children (P1, 174 (46.6%), P2, 115 (30.8%), P3, 65 (17.4%) and P4, 19 (5.1%)) was monitored. However, an increase in the number of HIV diagnoses by sexual contact (P1: 0%; P2: 1.3%; P3: 4.6%; P4: 16%) was observed. The rates of new perinatal HIV diagnoses and perinatal transmission in Spanish children decreased from 0.167 to 0.005 per 100,000 inhabitants and 11.4% to 0.4% between 1997 and 2015, respectively.
[Conclusions] A decline of perinatal HIV diagnoses and transmission was observed. However, an increase of teen-agers HIV diagnoses with sexual infection was studied. Public awareness campaigns directed to teen-agers are advisable to prevent HIV infection by sexual contact.
2020-05-29T09:18:35Z
2020-05-29T09:18:35Z
2019-10-24
artículo
PLoS ONE 14(10): e0223536 (2019)
10.1371/journal.pone.0223536
http://hdl.handle.net/10261/212663
1932-6203
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/100000002
http://dx.doi.org/10.13039/100004440
http://dx.doi.org/10.13039/100000011
http://dx.doi.org/10.13039/501100000780
eng
Publisher's version
https://doi.org/10.1371/journal.pone.0223536
Sí
http://creativecommons.org/licenses/by/4.0/
openAccess
Public Library of Science