2024-03-28T19:38:40Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2009982020-10-13T12:43:53Zcom_10261_5063com_10261_5col_10261_5066
Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles
Leitner, S.
Solans, Conxita
García-Celma, M. J.
Calderó, Gabriela
Ministerio de Economía y Competitividad (España)
Calderó, Gabriela [0000-0003-4827-7722]
Cationic nano-emulsion
Cationic nanoparticles
Ethylcellulose nanoparticles
Low-energy emulsifiaction
Positively charged ethylcelulose nanoparticles have been obtained from alkylamidoammonium/Span 80 based nano-emulsion templates. Oil-in-water polymeric nano-emulsions form in a broad range of oil-to-surfactant ratios and water contents above 75 wt% by a low-energy method at 25 °C. Nano-emulsions with a water content of 90 wt% showed droplet sizes typically below 300 nm and high positive zeta potential values (∼55 mV). If oleylamine is added to the system, smaller droplet sizes and higher zeta potential values (∼66 mV) are obtained, but the stability of the nano-emulsions decreases. Although these nano-emulsions are destabilized by creaming, the period of stability is large enough to allow nanoparticle preparation by solvent evaporation. Polymeric nanoparticles obtained show a globular core-shell-like morphology, with mean diameters of around 250 nm. The surface charge of the nanoparticles is similar to that of the nano-emulsion template and remains positive after 24 h dialysis, suggesting slow desorption kinetics of the alkylamidoammonium from the nanoparticle surface. These results indicate that the proposed nano-emulsion approach is a good strategy for the preparation of positively charged nanoparticles from nonionic ethylcellulose polymers. © 2018 Elsevier Ltd
2020-02-18T07:48:42Z
2020-02-18T07:48:42Z
2019-02-01
artículo
Carbohydrate Polymers 205: 117-124 (2019)
http://hdl.handle.net/10261/200998
10.1016/j.carbpol.2018.10.025
http://dx.doi.org/10.13039/501100003329
eng
Postprint
Sí
openAccess
Elsevier