2024-03-28T17:51:57Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1744032020-12-13T09:23:38Zcom_10261_108com_10261_8col_10261_361
The Anopheles gambiae transcriptome – a turning point for malaria control
Domingos, Ana
Pinheiro-Silva, Renato
Couto, Joana
Rosário, V. do
Fuente, José de la
Fundação para a Ciência e a Tecnologia (Portugal)
Anopheles gambiae
Plasmodium spp
Malaria
Vector
Transcriptomics
Mosquitoes are important vectors of several pathogens and thereby contribute to the spread of diseases, with social, economic and public health impacts. Amongst the approximately 450 species of Anopheles, about 60 are recognized as vectors of human malaria, the most important parasitic disease. In Africa, Anopheles gambiae is the main malaria vector mosquito. Current malaria control strategies are largely focused on drugs and vector control measures such as insecticides and bed-nets. Improvement of current, and the development of new, mosquito-targeted malaria control methods rely on a better understanding of mosquito vector biology. An organism's transcriptome is a reflection of its physiological state and transcriptomic analyses of different conditions that are relevant to mosquito vector competence can therefore yield important information. Transcriptomic analyses have contributed significant information on processes such as blood-feeding parasite–vector interaction, insecticide resistance, and tissue- and stage-specific gene regulation, thereby facilitating the path towards the development of new malaria control methods. Here, we discuss the main applications of transcriptomic analyses in An. gambiae that have led to a better understanding of mosquito vector competence.
2019-01-21T10:05:02Z
2019-01-21T10:05:02Z
2017
2019-01-21T10:05:03Z
artículo
Insect Molecular Biology 26(2): 140-151 (2017)
http://hdl.handle.net/10261/174403
10.1111/imb.12289
http://dx.doi.org/10.13039/501100001871
eng
Sí
closedAccess
Royal Entomological Society (Great Britain)
John Wiley & Sons