2024-03-29T11:05:07Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1710752020-12-13T09:10:12Zcom_10261_70com_10261_2com_10261_31891col_10261_323col_10261_31892
Updating the research on the chemopreventive and therapeutic role of the peptide lunasin
Hsieh, Chia-Chien
Martínez Villaluenga, Cristina
Lumen, Ben O. de
Hernández-Ledesma, Blanca
Ministry of Science and Technology (Taiwan)
Ministerio de Economía y Competitividad (España)
Chronic diseases
Cancer
Lunasin
Chemopreventive and therapeutic properties
Bioactive peptides
Chronic diseases have become the medical challenge of the 21st century because of their high incidence and mortality rates. Modulation of diet and lifestyle habits is considered as the best strategy for the prevention of these disorders. Health promoting benefits beyond their nutritional effects have been described for multiple dietary compounds. Among these compounds, the peptide lunasin is considered as one of the most promising. Naturally present in soybean, lunasin has been extensively studied in the last two decades because of its potential against chronic diseases such as cancer, cardiovascular and immunological disorders. The purpose of this article is to summarise the evidence on the presence of lunasin in soybean and derived foods, and its bioavailability once it is orally ingested. The protective and therapeutic effects of this peptide against cancer, oxidative stress, inflammation, and high cholesterol levels as well as the molecular mechanisms of action involved in these effects are also described in this review.
2018-10-16T09:19:02Z
2018-10-16T09:19:02Z
2018
2018-10-16T09:19:03Z
artículo
Journal of the Science of Food and Agriculture 98(6): 2070-2079 (2018)
http://hdl.handle.net/10261/171075
10.1002/jsfa.8719
http://dx.doi.org/10.13039/501100003329
28990666
eng
Postprint
https://doi.org/10.1002/jsfa.8719
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-43247-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-66886-R
openAccess
Society of Chemical Industry
John Wiley & Sons