2024-03-28T16:55:45Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1645052020-12-13T09:28:29Zcom_10261_3284com_10261_1col_10261_3285
Germline development in amniotes: A paradigm shift in primordial germ cell specification
Bertocchini, Federica
Chuva de Sousa Lopes, Susana M.
Belgian Science Policy Office
Ministerio de Ciencia e Innovación (España)
Fundación Ramón Areces
Mammals
Amniotes
Chickens
Epigenesis
Evolution
Preformation
Primordial germ cells
In the field of germline development in amniote vertebrates, primordial germ cell (PGC) specification in birds and reptiles remains controversial. Avians are believed to adopt a predetermination or maternal specification mode of PGC formation, contrary to an inductive mode employed by mammals and, supposedly, reptiles. Here, we revisit and review some key aspects of PGC development that channelled the current subdivision, and challenge the position of birds and reptiles as well as the ‘binary’ evolutionary model of PGC development in vertebrates. We propose an alternative view on PGC specification where germ plasm plays a role in laying the foundation for the formation of PGC precursors (pPGC), but not necessarily of PGCs. Moreover, inductive mechanisms may be necessary for the transition from pPGCs to PGCs. Within this framework, the implementation of data from birds and reptiles could provide new insights on the evolution of PGC specification in amniotes.
2018-05-08T07:40:05Z
2018-05-08T07:40:05Z
2016
2018-05-08T07:40:05Z
artículo
BioEssays 38(8): 791-800 (2016)
http://hdl.handle.net/10261/164505
10.1002/bies.201600025
http://dx.doi.org/10.13039/100008054
http://dx.doi.org/10.13039/501100004837
27273724
eng
Publisher's version
https://doi.org/10.1002/bies.201600025
Sí
http://creativecommons.org/licenses/by/4.0/
openAccess
Wiley-VCH