2024-03-29T13:17:23Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1581232021-12-27T15:40:33Zcom_10261_56com_10261_3col_10261_309
Hydrogels for Cartilage Regeneration, from Polysaccharides to Hybrids
Sánchez-Téllez, Daniela Anahí
Téllez-Jurado, Lucía
Rodríguez-Lorenzo, Luis M.
Consejo Superior de Investigaciones Científicas (España)
Ministerio de Economía, Industria y Competitividad (España)
Cartilage regeneration
Polymeric hydrogels
Polysaccharides
Hybrid hydrogels
Hybrid scaffolds
The aims of this paper are: (1) to review the current state of the art in the field of cartilage
substitution and regeneration; (2) to examine the patented biomaterials being used in preclinical
and clinical stages; (3) to explore the potential of polymeric hydrogels for these applications and the
reasons that hinder their clinical success. The studies about hydrogels used as potential biomaterials
selected for this review are divided into the two major trends in tissue engineering: (1) the use of
cell-free biomaterials; and (2) the use of cell seeded biomaterials. Preparation techniques and resulting
hydrogel properties are also reviewed. More recent proposals, based on the combination of different
polymers and the hybridization process to improve the properties of these materials, are also reviewed.
The combination of elements such as scaffolds (cellular solids), matrices (hydrogel-based), growth
factors and mechanical stimuli is needed to optimize properties of the required materials in order to
facilitate tissue formation, cartilage regeneration and final clinical application. Polymer combinations
and hybrids are the most promising materials for this application. Hybrid scaffolds may maximize
cell growth and local tissue integration by forming cartilage-like tissue with biomimetic features
2017-12-12T14:01:00Z
2017-12-12T14:01:00Z
2017
artículo
Polymers 9(12): 671 (2017)
2073-4360
http://hdl.handle.net/10261/158123
10.3390/polym9120671
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100010198
30965974
eng
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2014-51918-C2-I-R
openAccess
Multidisciplinary Digital Publishing Institute