2024-03-30T01:36:05Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1577822017-12-18T14:33:49Zcom_10261_39com_10261_1col_10261_1174
The calcium-sensing receptor in health and disease
Díaz-Soto, G.
Rocher, Asunción
García-Rodríguez, Carmen
Núñez, Lucía
Villalobos, Carlos
Ministerio de Economía y Competitividad (España)
European Commission
Junta de Castilla y León
Instituto de Salud Carlos III
The extracellular calcium-sensing receptor (CaSR) is a unique G protein–coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations including Mg2+, amino acids, and polyamines. CaSR is the most important master controller of the extracellular Ca2+ homeostatic system being expressed at high levels in the parathyroid gland, kidney, gut and bone, where it regulates parathyroid hormone (PTH) secretion, vitamin D synthesis, and Ca2+ absorption and resorption, respectively. Gain and loss of function mutations in the CaSR are responsible for severe disturbances in extracellular Ca2+ metabolism. CaSR agonists (calcimimetics) and antagonists (calcilytics) are in use or under intense research for treatment of hyperparathyroidism secondary to kidney failure and hypocalcemia with hypercalciuria, respectively. Expression of the CaSR extends to other tissues and systems beyond the extracellular Ca2+ homeostatic system including the cardiovascular system, the airways, and the nervous system where it may play physiological functions yet to be fully understood. As a consequence, CaSR has been recently involved in different pathologies including uncontrolled blood pressure, vascular calcification, asthma, and Alzheimer's disease. Finally, the CaSR has been shown to play a critical role in cancer either contributing to bone metastasis and/or acting as a tumor suppressor in some forms of cancer (parathyroid cancer, colon cancer, and neuroblastoma) and as oncogene in others (breast and prostate cancers). Here we review the role of CaSR in health and disease in calciotropic tissues and others beyond the extracellular calcium homeostatic system.
2017-11-27T13:48:45Z
2017-11-27T13:48:45Z
2016
2017-11-27T13:48:45Z
capítulo de libro
International Review of Cell and Molecular Biology 327: 321-369 (2016)
http://hdl.handle.net/10261/157782
10.1016/bs.ircmb.2016.05.004
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100014180
eng
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-44521-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-70131-R
closedAccess
Elsevier