2024-03-29T12:20:02Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1564862021-05-12T11:08:29Zcom_10261_54com_10261_1col_10261_307
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
Moratalla, Rosario
Khairnar A
Simola N
Granado, Noelia
García-Montes JR
Porceddu PF
Tizabi Y
Costa G
Morelli M.
Ministerio de Economía y Competitividad (España)
Ministerio de Sanidad y Política Social (España)
Instituto de Salud Carlos III
Comunidad de Madrid
Regione Autonoma della Sardegna
European Commission
Rat
Non-human primate
Neuroinflammation neurotoxicity
Neurodegeneration
Mouse
Methamphetamine
3,4-Methylenedioxymethamphetamine
MDMA
Ecstasy
METH
Dopamine
Abstract
Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and non-human primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse.
Copyright © 2015. Published by Elsevier Ltd.
2017-10-20T10:57:07Z
2017-10-20T10:57:07Z
2015
2017-10-20T10:57:07Z
artículo
Progress in Neurobiology 5: 58- 63 (2015)
http://hdl.handle.net/10261/156486
10.1016/j.pneurobio.2015.09.011
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100009873
eng
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-48532-R
S2011/BMD-2336/NEUROSTEM
openAccess
Pergamon Press