2024-03-29T01:02:23Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1375172018-08-29T07:51:22Zcom_10261_64com_10261_1col_10261_317
Relationship between proinflammatory and antioxidant proteins with the severity of cardiovascular disease in type 2 diabetes mellitus
García-Fontana, Beatriz
Morales-Santana, Sonia
Longobardo, Victoria
Reyes-García, Rebeca
Rozas-Moreno, Pedro
García-Salcedo, José Antonio
Muñoz Torres, Manuel
Instituto de Salud Carlos III
Junta de Andalucía
European Commission
Consejo Superior de Investigaciones Científicas (España)
Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (España)
Cardiovascular disease
Type 2 diabetes mellitus
Proinflammation
Proteomic
Oxidative stress
Type 2 diabetes mellitus patients are at significant risk of cardiovascular disease, however, the pathophysiology of these complications is complex and incompletely known in this population. The aim of this study was to compare the serum proteome of patients with type 2 diabetes mellitus presenting or not presenting cardiovascular disease with non-diabetic subjects to find essential proteins related to these cardiovascular complications. This cross-sectional study compares the serum proteome by a combination of protein depletion with 2D-DIGE (2-dimension Difference Gel Electrophoresis) methodology. The proteins differentially expressed were identified by MALDI TOF/TOF (Matrix-assisted laser desorption/ionization and Time-Of-Flight ion detector) or LC-MS/MS (Liquid Chromatography coupled to Mass-Mass Spectrometry). Type 2 diabetes mellitus patients with cardiovascular disease showed higher expression of plasma retinol binding protein and glutathione peroxidase-3 compared to those without cardiovascular disease and non-diabetic controls. These results show that proteins related to the inflammatory and redox state appear to play an important role in the pathogenesis of the cardiovascular disease in the type 2 diabetes mellitus patients. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
2016-09-30T09:31:20Z
2016-09-30T09:31:20Z
2015-04-27
2016-09-30T09:31:20Z
artículo
International Journal of Molecular Sciences 16(5): 9469-9483 (2015)
http://hdl.handle.net/10261/137517
10.3390/ijms16059469
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100011011
25923078
eng
Publisher's version
http://dx.doi.org/10.3390/ijms16059469
Sí
http://creativecommons.org/licenses/by-nc-sa/4.0/
openAccess
Multidisciplinary Digital Publishing Institute