2024-03-28T11:10:29Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1353112017-06-15T10:59:05Zcom_10261_89com_10261_3com_10261_36com_10261_4col_10261_468col_10261_415
Mechanical properties of systems with biological interest: The human Immunoglobulin G
Vilhena, J. G.
Pérez, Rubén
Serena, Pedro A.
García García, Ricardo
Póster presentado en el Congreso Fuerzas y Tunel, celebrado en San Lorenzo de El Escorial del 12 al 14 de septiembre de 2012.
The antibodies are the first line of differentiated defense mechanism of
our body. A better understanding of the mechanical properties of such
structures would allow us to use this information as an extremely accurate
diagnostic tool. The method we rely on to obtain such detailed information is the
multi-frequency atomic force microscopy (AFM)[1]. The AFM has several
features that are attractive to the biologists. First, it is a tool with molecular
resolution that enables imaging in physiologic-like environments[2] and
secondly it also provides nano-mechanical and chemical information at time
scale relevant for bio-molecular interactions.
Dynamic AFM imagesof biological molecules on ambient conditions
(liquid) are controlled by nonlinear tip-sample interaction, the cantilever
dynamics and the feedback control. In order to extract accurate information
about topography and materials properties, these effects have to be taken into
account simultaneously. Here we report how to improve the theoretical
description of each of these aspects and integrate them into a multi-scale
framework that incorporates different levels of computer modeling in order to
address the ultimate spacial resolution and force sensitivity of the AFM on
biological molecules.
2016-08-04T09:06:03Z
2016-08-04T09:06:03Z
2012-09
2016-08-04T09:06:04Z
póster de congreso
Congreso Fuerzas y Tunel (2012)
http://hdl.handle.net/10261/135311
eng
Sí
openAccess