2024-03-29T06:05:25Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1346732018-09-07T07:30:59Zcom_10261_112com_10261_1col_10261_365
Anaphylaxis as a clinical manifestation of clonal mast cell disorders
Matito, Almudena
Álvarez-Twose, Iván
Morgado, J. M.
Sánchez-Muñoz, Laura
Orfao, Alberto
Escribano, Luis
Indolent systemic mastocytosis in the absence of skin lesion
KIT mutation
Clonal mast cell disorders
Anaphylaxis
Clonal mast cell disorders comprise a heterogeneous group of disorders characterized by the presence of gain of function KIT mutations and a constitutively altered activation-associated mast cell immunophenotype frequently associated with clinical manifestations related to the release of mast cells mediators. These disorders do not always fulfil the World Health Organization (WHO)-proposed criteria for mastocytosis, particularly when low-sensitive diagnostic approaches are performed. Anaphylaxis is a frequent presentation of clonal mast cell disorders, particularly in mastocytosis patients without typical skin lesions. The presence of cardiovascular symptoms, e.g., hypotension, occurring after a hymenoptera sting or spontaneously in the absence of cutaneous manifestations such as urticaria is characteristic and differs from the presentation of anaphylaxis in the general population without mastocytosis.
2016-07-12T06:55:36Z
2016-07-12T06:55:36Z
2014
2016-07-12T06:55:36Z
artículo
Current Allergy and Asthma Reports 14(8): 450 (2014)
http://hdl.handle.net/10261/134673
10.1007/s11882-014-0450-8
eng
Sí
closedAccess
Springer