2024-03-28T11:20:04Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1316982021-06-30T07:49:13Zcom_10261_86com_10261_1com_10261_69com_10261_2col_10261_339col_10261_322
Current trends in capsular polysaccharide biosynthesis of Streptococcus pneumoniae
García, Ernesto
Llull, Daniel
Muñoz, Rosario
Mollerach, M.
López, Rubens
Ministerio de Educación y Cultura (España)
Dirección General de Investigación Científica y Técnica, DGICT (España)
The capsular gene cluster (cap/cps) of 13 out of the 90 known pneumococcal types has been sequenced. The cap/cps operon, located between dexB and aliA in the Streptococcus pneumoniae chromosome, contains some of the genes responsible for the synthesis of the type-specific polysaccharide flanked by four conserved open reading frames. The biochemical function of only a few capsular genes has been established, whereas the role of the flanking regions is controversial. Remarkably, only one gene (tts) located outside the cap locus is required for the synthesis of type 37 capsule. Moreover, other genes not linked to the cap gene cluster are also needed for capsule synthesis in pneumococcus.
2016-05-04T11:29:51Z
2016-05-04T11:29:51Z
2000-07-08
2016-05-04T11:29:51Z
artículo
Research in Microbiology 151(6): 429–435 (2000)
http://hdl.handle.net/10261/131698
10.1016/S0923-2508(00)00173-X
http://dx.doi.org/10.13039/501100008737
eng
http://dx.doi.org/10.1016/S0923-2508(00)00173-X
Sí
closedAccess
Elsevier