2024-03-29T13:40:57Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1246262021-06-14T11:25:08Zcom_10261_79com_10261_1col_10261_332
Global Metabolomic Profiling of Acute Myocarditis Caused by Trypanosoma cruzi Infection
Gironès, Núria
Carbajosa, Sofía
Guerrero, Néstor A.
Poveda, Cristina
Chillón-Marinas, Carlos
Fresno, Manuel
Ministerio de Ciencia e Innovación (España)
Fundación Ramón Areces
Ministerio de Asuntos Exteriores y Cooperación (España)
European Commission
Universidad Autónoma de Madrid
Comunidad de Madrid
© 2014 Gironès et al. Chagas disease is caused by Trypanosoma cruzi infection, being cardiomyopathy the more frequent manifestation. New chemotherapeutic drugs are needed but there are no good biomarkers for monitoring treatment efficacy. There is growing evidence linking immune response and metabolism in inflammatory processes and specifically in Chagas disease. Thus, some metabolites are able to enhance and/or inhibit the immune response. Metabolite levels found in the host during an ongoing infection could provide valuable information on the pathogenesis and/or identify deregulated metabolic pathway that can be potential candidates for treatment and being potential specific biomarkers of the disease. To gain more insight into those aspects in Chagas disease, we performed an unprecedented metabolomic analysis in heart and plasma of mice infected with T. cruzi. Many metabolic pathways were profoundly affected by T. cruzi infection, such as glucose uptake, sorbitol pathway, fatty acid and phospholipid synthesis that were increased in heart tissue but decreased in plasma. Tricarboxylic acid cycle was decreased in heart tissue and plasma whereas reactive oxygen species production and uric acid formation were also deeply increased in infected hearts suggesting a stressful condition in the heart. While specific metabolites allantoin, kynurenine and p-cresol sulfate, resulting from nucleotide, tryptophan and phenylalanine/tyrosine metabolism, respectively, were increased in heart tissue and also in plasma. These results provide new valuable information on the pathogenesis of acute Chagas disease, unravel several new metabolic pathways susceptible of clinical management and identify metabolites useful as potential specific biomarkers for monitoring treatment and clinical severity in patients.
2015-11-06T12:27:08Z
2015-11-06T12:27:08Z
2014-11-20
2015-11-06T12:27:08Z
artículo
PLoS Neglected Tropical Diseases 8 (2014)
http://hdl.handle.net/10261/124626
10.1371/journal.pntd.0003337
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/100008054
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100004593
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100003767
25412247
eng
Publisher's version
Sí
openAccess
Public Library of Science