2024-03-28T11:44:45Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1169692019-03-21T13:02:21Zcom_10261_41com_10261_1col_10261_294
Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
Manichanh, Chaysavanh
Roca, Joaquim
Azpiroz, Fernando
Intestinal gas
Bloating
Diet
Dysbiosis
Microbial instability
Chaysavanh Manichanh et al.
Objective: To characterise the influence of diet on abdominal symptoms, anal gas evacuation, intestinal gas distribution and colonic microbiota in patients complaining of flatulence. Design Patients complaining of flatulence (n=30) and healthy subjects (n=20) were instructed to follow their usual diet for 3 days (basal phase) and to consume a high-flatulogenic diet for another 3 days (challenge phase). Results: During basal phase, patients recorded more abdominal symptoms than healthy subjects in daily questionnaires (5.8±0.3 vs 0.4±0.2 mean discomfort/pain score, respectively; p=<0.0001) and more gas evacuations by an event marker (21.9±2.8 vs 7.4±1.0 daytime evacuations, respectively; p=0.0001), without differences in the volume of gas evacuated after a standard meal (262±22 and 265±25 mL, respectively). On flatulogenic diet, both groups recorded more abdominal symptoms (7.9±0.3 and 2.8±0.4 discomfort/pain, respectively), number of gas evacuations (44.4±5.3 and 21.7±2.9 daytime evacuations, respectively) and had more gas production (656±52 and 673±78 mL, respectively; p<0.05 vs basal diet for all). When challenged with flatulogenic diet, patients' microbiota developed instability in composition, exhibiting variations in the main phyla and reduction of microbial diversity, whereas healthy subjects¿ microbiota were stable. Taxa from Bacteroides fragilis or Bilophila wadsworthia correlated with number of gas evacuations or volume of gas evacuated, respectively. Conclusions Patients complaining of flatulence have a poor tolerance of intestinal gas, which is associated with instability of the microbial ecosystem
2015-06-22T11:06:58Z
2015-06-22T11:06:58Z
2014-03
2015-06-22T11:06:58Z
artículo
Gut 63(3): 401-408 (2014)
http://hdl.handle.net/10261/116969
10.1136/gutjnl-2012-303013
23766444
eng
Postprint
http://dx.doi.org/10.1136/gutjnl-2012-303013
info:eu-repo/grantAgreement/EC/FP7/261376
openAccess
BMJ Publishing Group