2024-03-29T14:20:33Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1140462021-05-12T12:41:53Zcom_10261_105com_10261_1col_10261_358
Intestinal preconditioning is mediated by a transient increase in nitric oxide
Hotter, Georgina
Closa, Daniel
Prados, M.C.
Fernández-Cruz, Laureano
Prats, Neus
Gelpí, Emili
Roselló-Catafau, Joan
The effect of ischemic preconditioning on the intestine, as well the implication of nitric oxide and prostacyclin in this process has been evaluated. Thus, intestinal ischemia-reperfusion was induced in rats, and the protection conferred by previous preconditioning was evaluated. In addition, the effect of nitric oxide inhibition and the administration of nitric oxide were determined. Results show that the increases observed in LDH release after ischemia-reperfusion were prevented after preconditioning. Inhibition of nitric oxide synthesis abolished the protective effect of preconditioning, and nitric oxide administration replicated this effect. Also, an increased synthesis of nitric oxide has been detected after preconditioning. Increases in 6 keto PGF(1α) were independent of nitric oxide. Altogether indicates that preconditioning is triggered by an initial increase in nitric oxide synthesis.
2015-04-23T08:18:59Z
2015-04-23T08:18:59Z
1996-05-01
2015-04-23T08:18:59Z
artículo
Biochemical and Biophysical Research Communications 222(1): 27-32 (1996)
http://hdl.handle.net/10261/114046
10.1006/bbrc.1996.0692
eng
http://dx.doi.org/10.1006/bbrc.1996.0692
closedAccess
Academic Press