2024-03-28T19:42:54Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/105182009-02-10T16:57:50Zcom_10261_5062com_10261_5col_10261_5064
LC-MS for identifying photodegradation products of pharmaceuticals in the environment
Petrovic, Mira
Barceló, Damià
Liquid chromatography
Mass spectrometry
Pharmaceuticals
Photodegradation
Transformation product
8 pages, 4 figures, 1 table.-- Printed version published Jun 2007.-- Issue title: Pharmaceutical-residue analysis.
Abiotic processes, such as direct and indirect photolysis, are of great importance in determining the aquatic fate of pharmaceutical compounds. Photolytic reactions are often complex, involving various competing or parallel
pathways and leading to multiple reaction products. The identification of transformation products and the elucidation of photolysis-reaction pathways are of crucial importance in understanding their fate in the aquatic environment, but are complicated and cumbersome.
This article focuses on advanced liquid chromatography-mass spectrometry (LC-MS) methods for identifying transformation products of abiotic processes that lead to the transformation of pharmaceutical compounds in
environmental systems (direct and indirect photolysis) and photocatalytic transformations in water- and wastewater-treatment systems, using titanium dioxide or the photo-Fenton process.
We discuss the capabilities and the limitations of single-MS, tandem-MS and hybrid-MS techniques, and present practical examples (triple-quadrupole-MS analysis of phototransformation products of fluoxetine, ion-trap-MS analysis of photoproducts of carbamazepine, and time-of-flight-MS elucidation
of the reaction pathways of photolytic and photocatalytic degradation of diclofenac).
2009-02-10T11:31:06Z
2009-02-10T11:31:06Z
2007-02-24
artículo
TrAC-Trends in Analytical Chemistry 26(6): 486-493 (2007)
0167-2940
http://hdl.handle.net/10261/10518
10.1016/j.trac.2007.02.010
eng
http://dx.doi.org/10.1016/j.trac.2007.02.010
closedAccess
Elsevier