2024-03-28T12:53:14Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/521892019-11-06T10:57:20Zcom_10261_41com_10261_1col_10261_294
Closca, a new gene required for both Torso RTK activation and vitelline membrane integrity. Germline proteins contribute to Drosophila eggshell composition
Ventura, Gemma
Furriols, Marc
Martín, Nicolás
Barbosa, Vitor
Casanova, Jordi
The Drosophila eggshell is a specialised extracellular matrix (ECM) that surrounds and protects the oocyte and the embryo until its eclosion. In addition, the vitelline membrane, the innermost layer of the eggshell, holds the local determinant required to activate the Torso RTK pathway, which establishes the embryonic terminal regions. Here we report the identification and characterisation of closca, a gene encoding a new member of a group of proteins that act non-redundantly in vitelline membrane biogenesis and in Torso signalling. We also show that the Nasrat protein, another member of this group, is incorporated into the vitelline membrane, thereby indicating that the eggshell is a shared ECM that receives contributions from both follicle cells and the germline. This observation also provides a new scenario that accounts for the long known contribution of germline products to vitelline membrane biogenesis and to the follicle cell-dependent activation of the Torso receptor. © 2010 Elsevier Inc.
2012-06-26T08:05:36Z
2012-06-26T08:05:36Z
2010-08-01
2012-06-26T08:05:37Z
artículo
http://purl.org/coar/resource_type/c_6501
issn: 0012-1606
Developmental Biology 344(1): 224-232 (2010)
http://hdl.handle.net/10261/52189
10.1016/j.ydbio.2010.05.002
en
http://doi.org/10.1016/j.ydbio.2010.05.002
none
Elsevier