2024-03-28T15:38:18Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2305402022-11-22T13:55:13Zcom_10261_108com_10261_8com_10261_2288com_10261_9col_10261_361col_10261_204074
A dataset for the analysis of antibody response to glycan alpha-Gal in individuals with immune-mediated disorders [version 1; peer review: 1 approved]
Fuente, José de la
Urra, José Miguel
Contreras, Marinela
Pacheco, Iván
Ferreras-Colino, Elisa
Doncel-Pérez, Ernesto
Fernández de Mera, Isabel G.
Villar, Margarita
Cabrera, Carmen M.
Gómez Hernando, Cesar
Vargas Baquero, Eduardo
Blanco García, Javier
Rodríguez Gómez, Javier
Velayos Galán, Alberto
Feo Brito, Francisco
Gómez Torrijos, Elisa
Cabezas-Cruz, Alejandro
Gortázar, Christian
Universidad de Castilla La Mancha
Alpha gal
Immune response
Tick
COVID-19
Coronavirus
Guillain-Barré syndrome
Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response mediated by anti-α-Gal IgM/IgG/IgA antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can develop the alpha-Gal syndrome (AGS), a recently diagnosed disease mediated by anti-α-Gal IgE antibodies and associated with allergic reactions to mammalian meat consumption and tick bites. However, the anti-α-Gal antibody response may be associated with other immune-mediated disorders such as those occurring in patients with COVID-19 and Guillain-Barré syndrome (GBS). Here, we provide a dataset (209 entries) on the IgE/IgM/IgG/IgA anti-α-Gal antibody response in healthy individuals and patients diagnosed with AGS, tick-borne allergies, GBS and COVID-19. The data allows correlative analyses of the anti-α-Gal antibody response with factors such as patient and clinical characteristics, record of tick bites, blood group, age and sex. These analyses could provide insights into the role of anti-α-Gal antibody response in disease symptomatology and possible protective mechanisms.
We acknowledge UCLM, Spain support to Group SaBio.
Peer reviewed
2021-02-24T10:53:17Z
2021-02-24T10:53:17Z
2021
artículo
http://purl.org/coar/resource_type/c_6501
F1000Research 9: 1366 (2021)
http://hdl.handle.net/10261/230540
10.12688/f1000research.27495.1
2046-1402
http://dx.doi.org/10.13039/501100007480
en
Publisher's version
https://doi.org/10.12688/f1000research.27495.1
Sí
open
F1000Research