2024-03-29T00:47:35Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2200092020-09-23T01:08:55Zcom_10261_31891com_10261_2col_10261_31892
Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation
Zapata, Fatima J.
Rebollo-Hernanz, Miguel
Novakofski, Jan E.
Nakamura, Manabu T.
González de Mejía, Elvira
University of Illinois
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Caffeine
Yerba mate
Fat accumulation
Lipogenesis
Ilex paraguariensis
Obesity
The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.
The Division of Nutritional Sciences, University of Illinois fully funded this research through the 20/20 initiative. M. Rebollo-Hernanz received funding from the program of the Ministry of Science, Innovation, and Universities for his predoctoral fellowship (FPU15/04238) and the support for the international research at the University of Illinois, Urbana–Champaign (EST18/0064).
Peer reviewed
2020-09-22T09:09:20Z
2020-09-22T09:09:20Z
2020
artículo
http://purl.org/coar/resource_type/c_6501
Journal of Functional Foods 64: 103646 (2020)
1756-4646
http://hdl.handle.net/10261/220009
10.1016/j.jff.2019.103646
http://dx.doi.org/10.13039/100010443
http://dx.doi.org/10.13039/501100011033
en
Publisher's version
https://doi.org/10.1016/j.jff.2019.103646
Sí
open
Elsevier