2024-03-29T02:23:03Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2156592022-03-03T14:05:53Zcom_10261_31com_10261_3com_10261_35com_10261_5com_10261_240028col_10261_284col_10261_288col_10261_240055
Intratumoral versus circulating lymphoid cells as predictive biomarkers in lung cancer patients treated with immune checkpoint inhibitors: Is the easiest path the best one?
Gascón, Marta
Isla, Dolores
Cruellas, Mara
Gálvez Buerba, Eva Mª
Lastra, Rodrigo
Ocáriz, Maitane
Paño, José Ramón
Ramírez-Labrada, Ariel
Sesma, Andrea
Torres-Ramón, Irene
Yubero, Alfonso
Pardo, Julián
Martínez-Lostao, Luis
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Gobierno de Aragón
European Commission
This article belongs to the Special Issue Cancer Immunology: From Molecular Mechanisms to Therapeutic Opportunities.
The molecular and cell determinants that modulate immune checkpoint (ICI) efficacy in lung cancer are still not well understood. However, there is a necessity to select those patients that will most benefit from these new treatments. Recent studies suggest the presence and/or the relative balance of specific lymphoid cells in the tumor microenvironment (TEM) including the T cell (activated, memory, and regulatory) and NK cell (CD56dim/bright) subsets, and correlate with a better response to ICI. The analyses of these cell subsets in peripheral blood, as a more accessible and homogeneous sample, might facilitate clinical decisions concerning fast prediction of ICI efficacy. Despite recent studies suggesting that lymphoid circulating cells might correlate with ICI efficacy and toxicity, more analyses and investigation are required to confirm if circulating lymphoid cells are a relevant picture of the lung TME and could be instrumental as ICI response biomarkers. This short review is aimed to discuss the recent advances in this fast-growing field.
J.P. reports research funding from BMS and Gilead and speaker honoraria from Gilead and Pfizer. E.M.G. reports research funding from BMS and Gilead. J.P. and E.M.G. are funded by FEDER (Fondo Europeo de Desarrollo Regional, Gobierno de Aragón (Group B29_17R), Ministerio de Ciencia, Innovación e Universidades (MCNU), Agencia Estatal de Investigación (SAF2017-83120-C2-1-R), Fundacion Inocente Inocente, ASPANOA and Carrera de la Mujer de Monzón. J.P. is supported by ARAID Foundation.
2020-06-30T16:33:38Z
2020-06-30T16:33:38Z
2020-06-22
2020-06-30T16:33:39Z
artículo
http://purl.org/coar/resource_type/c_6501
Cells 9(6): 1525 (2020)
http://hdl.handle.net/10261/215659
10.3390/cells9061525
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100010067
32580514
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-83120-C2-1-R
SAF2017-83120-C2-1-R/AEI/10.13039/501100011033
Publisher's version
https://doi.org/10.3390/cells9061525
open
Multidisciplinary Digital Publishing Institute