2024-03-28T18:55:19Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2079662020-08-11T08:05:59Zcom_10261_133com_10261_1col_10261_386
Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: The impact of the experimental design
Santis, Silvia de
Bastiani, Matteo
Droby, Amgad
Kolber, Pierre
Zipp, Frauke
Pracht, Eberhard
Stoecker, Tony
Groppa, Sergiu
Roebroeck, Alard
European Research Council
Brain and Behavior Research Foundation
Federal Ministry of Education and Research (Germany)
Netherlands Organization for Scientific Research
Multiple sclerosis
Multi-shell diffusion MRI
Ultra-high field MRI
Microstructure
The recent introduction of advanced magnetic resonance (MR) imaging techniques to characterize focal and global degeneration in multiple sclerosis (MS), like the Composite Hindered and Restricted Model of Diffusion, or CHARMED, diffusional kurtosis imaging (DKI) and Neurite Orientation Dispersion and Density Imaging (NODDI) made available new tools to image axonal pathology non-invasively in vivo. These methods already showed greater sensitivity and specificity compared to conventional diffusion tensor-based metrics (e.g., fractional anisotropy), overcoming some of its limitations.
While previous studies uncovered global and focal axonal degeneration in MS patients compared to healthy controls, here our aim is to investigate and compare different diffusion MRI acquisition protocols in their ability to highlight microstructural differences between MS and control tissue over several much used models. For comparison, we contrasted the ability of fractional anisotropy measurements to uncover differences between lesion, normal-appearing white matter (WM), gray matter and healthy tissue under the same imaging protocols. We show that: (1) focal and diffuse differences in several microstructural parameters are observed under clinical settings; (2) advanced models (CHARMED, DKI and NODDI) have increased specificity and sensitivity to neurodegeneration when compared to fractional anisotropy measurements; and (3) both high (3 T) and ultra-high fields (7 T) are viable options for imaging tissue change in MS lesions and normal appearing WM, while higher b-values are less beneficial under the tested short-time (10 min acquisition) conditions.
SDS is supported by a NARSAD Young Investigator Grant (Grant #25104) and by the European Research Council through a Marie Skłodowska-Curie Individual Fellowship (Grant #749506). MB is supported by the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013/ERC Grant Agreement #319456). This work was also supported by a grant from Federal Ministry for Education and Research (BMBF, KKNMS, project MSNetworks) to SG and FZ. AR is supported by Netherlands Organisation for Scientific Research through a VIDI grant (#14637).
Peer reviewed
2020-04-17T06:59:35Z
2020-04-17T06:59:35Z
2019-04-01
artículo
http://purl.org/coar/resource_type/c_6501
Neuroscience 403: 17-26 (2019)
0306-4522
http://hdl.handle.net/10261/207966
10.1016/j.neuroscience.2018.03.048
1873-7544
http://dx.doi.org/10.13039/501100002347
http://dx.doi.org/10.13039/501100000781
http://dx.doi.org/10.13039/100000874
en
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/749506
info:eu-repo/grantAgreement/EC/FP7/319456
Publisher's version
https://doi.org/10.1016/j.neuroscience.2018.03.048
Sí
open
Elsevier