2024-03-29T01:45:44Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/195732020-05-26T08:59:40Zcom_10261_31com_10261_3col_10261_284
Multipurpose box- and azabox-based immobilized chiral catalysts
Fraile, José M.
Pérez, Ignacio
Mayoral, José A.
Reiser, Oliver
Asymmetric catalysis
Azabis(oxazolines)
Cyclopropanation
Mukaiyama aldol
Supported catalysts
9 pages, 3 figures, 3 tables.
Azabis(oxazolines) can be used as chiral ligands in the copper-catalyzed enantioselective Mukaiyama aldol reaction. When supported on solids, azabis(oxazoline)-copper complexes are more easily deactivated than their analogous bis(oxazoline)-copper complexes, and are not compatible with the use of coordinating solvents in the method of preparation. The performance of the immobilized catalysts (up to 86 % ee) depends on the support and the reaction solvent, with some positive effect on enantioselectivity due to surface effects. The deactivation is not irreversible and the deactivated catalysts show excellent performance in the cyclopropanation reaction, providing added value to the supported multipurpose catalysts.
This work was supported by the C.I.C.Y.T. (project CTQ2005–08016), the DGA, and the Fonds der Chemischen Industrie. I. P. is indebted to the MEC for a grant.
Peer reviewed
2009-12-15T12:25:09Z
2009-12-15T12:25:09Z
2006-08-11
artículo
http://purl.org/coar/resource_type/c_6501
Advanced Synthesis and Catalysis 348(12-13): 1680 - 1688 (2006)
0935-9648
http://hdl.handle.net/10261/19573
10.1002/adsc.200606121
en
http://dx.doi.org/10.1002/adsc.200606121
none
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Wiley-VCH