2024-03-28T22:57:48Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1766742021-06-11T07:45:31Zcom_10261_115com_10261_3col_10261_368
Folding single chains to single-chain nanoparticles via reversible interactions: What size reduction can one expect?
Pomposo, José A.
Rubio-Cervilla, Jon
Moreno Segurado, Ángel J.
Lo Verso, Federica
Bačová, Petra
Arbe, Arantxa
Colmenero de León, Juan
Eusko Jaurlaritza
Ministerio de Economía y Competitividad (España)
Single-chain nanoparticles (SCNPs) constructed via reversible bonds are versatile stimuli-responsive soft nano-objects with potential use in nanomedicine, bioimaging, biosensing, and catalysis applications. In recent years, many different types of reversible SCNPs have been reported involving intrachain hydrogen bonding, host-guest interactions, and metal complex formation, among other reversible bonds. As illustrated in this work, reversible SCNPs in solution with similar nature, molar mass, and amount of reactive groups than irreversible (covalent-bonded) SCNPs display, on average, a lower level of chain compaction. We follow herein a Flory-like argument to obtain a simple expression providing the expected size reduction upon folding single chains of size R to SCNPs of size R with reversible interactions. Accurate estimation of R is of outmost importance for developing practical applications of responsive SCNPs based on structure-property relationships. For precursor chains having a fraction of groups x involved in reversible bonds, the expected size upon intrachain folding of the precursor chains to conventional SCNPs is given by R = R(1 - x). We perform a comparison of the size reduction predicted by the former expression with extensive literature data for SCNPs constructed via reversible bonds (72 SCNPs, 22 reversible interactions). The overall agreement between theoretical and experimental data is excellent, hence allowing a valuable a priori estimation of the size reduction upon folding single chains to single-chain nanoparticles via reversible interactions.
Financial support by the Spanish Ministry “Ministerio de Economia y Competitividad”, MAT2015-63704-P (MINECO/FEDER, UE) and the Basque Government, IT-654-13, is acknowledged.
Peer Reviewed
2019-02-25T12:04:01Z
2019-02-25T12:04:01Z
2017
2019-02-25T12:04:01Z
artículo
http://purl.org/coar/resource_type/c_6501
doi: 10.1021/acs.macromol.6b02427
e-issn: 1520-5835
issn: 0024-9297
Macromolecules 50(4): 1732-1739 (2017)
http://hdl.handle.net/10261/176674
10.1021/acs.macromol.6b02427
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100003086
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-63704-P
Postprint
https://doi.org/10.1021/acs.macromol.6b02427
Sí
open
American Chemical Society