2024-03-29T07:51:33Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1735382021-12-27T16:16:13Zcom_10261_28457com_10261_3col_10261_28462
CISNE: An accurate description of dose-effect and synergism in combination therapies
García-Fuente, Amador
Vázquez, Fernando
Viéitez, José M.
García Alonso, F. J.
Martín, José Ignacio
Ferrer, Jaime
Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología
Ministerio de Economía y Competitividad (España)
The precise determination of dose-effect curves and the combination effect of drugs is of crucial importance in the development of new therapies for the most dreadful diseases. We have found that the current implementations of the theory of Chou et al. are not accurate enough in some circumstances and might lead to erroneous predictions of synergistic or antagonistic behaviour. We have identified the source of inaccuracies and fixed it thereby improving the accuracy of those methods. Here we explain the main features of our approach and demonstrate its higher accuracy as compared to the standard methods. Therefore, this new implementation might have a huge impact in the reliability of future research on new Combination Therapies.
This work was supported by FICYT (grant GRUPIN14-121) and by the Spanish MINECO (project FIS2013-45469).
Peer Reviewed
2018-12-21T12:16:46Z
2018-12-21T12:16:46Z
2018
2018-12-21T12:16:46Z
artículo
http://purl.org/coar/resource_type/c_6501
doi: 10.1038/s41598-018-23321-6
e-issn: 2045-2322
Scientific Reports 8: 4964 (2018)
http://hdl.handle.net/10261/173538
10.1038/s41598-018-23321-6
http://dx.doi.org/10.13039/501100008430
http://dx.doi.org/10.13039/501100003329
29563526
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2013-45469-C4-1-R
Publisher's version
https://doi.org/10.1038/s41598-018-23321-6
Sí
open
Nature Publishing Group