2024-03-29T01:32:05Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1593132021-08-27T13:04:42Zcom_10261_79com_10261_1com_10261_86col_10261_332col_10261_339
New Agents Active against African Swine Fever Virus
Sola, Ana
Rodríguez, Silvia
Gil-Fernández, Carmen
Alarcón, Balbino
González, María Eugenia
Carrasco, Luis
Comisión Asesora de Investigación Científica y Técnica, CAICYT (España)
Actinobolin, atropine, carrageenan, megalomycin C, suramin, and tetracenomycin C were tested for their activity against African swine fever virus replication. Both viral inhibitory potency and cytotoxicity were investigated. Megalomycin C, suramin, atropine, and carrageenan exhibited significant activity. Megalomycin C was the most active of the four agents with respect to the concentration of compound that blocked the
formation of infectious virus by 50%. Suramin was the next most active agent in this respect, but because of its lower cytotoxicity, it had the most favorable therapeutic index
Fondo de Investigaci6n Sanitaria, Comisión Asesora de Investigación Cientifica Tecnica (CAICYT), and Plan Concertado 41/82, Antibioticos S.A.
Peer reviewed
2018-01-19T11:29:33Z
2018-01-19T11:29:33Z
1985-11-14
artículo
http://purl.org/coar/resource_type/c_6501
Antimicrobial Agents and Chemotherapy
0066-4804
http://hdl.handle.net/10261/159313
http://dx.doi.org/10.13039/501100007272
en
Publisher's version
Sí
open
American Society for Microbiology