2024-03-19T01:12:33Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1429982021-11-22T12:46:01Zcom_10261_11773com_10261_1col_10261_11774
Disruptive chemicals, senescence and immortality
Carnero, Amancio
Blanco-Aparicio, Carmen
Yasaei, Hemad
Japan Science and Technology Agency
National Centre for the Replacement, Refinement and Reduction of Animals in Research (UK)
Instituto de Salud Carlos III
Ministerio de Economía y Competitividad (España)
Red Temática de Investigación Cooperativa en Cáncer (España)
European Commission
Ministerio de Ciencia e Innovación (España)
Junta de Andalucía
National Institute of Environmental Health Sciences (US)
Maine Center for Toxicology and Environmental Health
National Institutes of Health (US)
Kuwait Foundation for the Advancement of Sciences
Ministry of Education, Culture, Sports, Science and Technology (Japan)
Department of Science and Technology (India)
U.S. Public Health Service
Università degli Studi di Firenze
Ministry of Education (Malaysia)
Ministero dell'Istruzione, dell'Università e della Ricerca
Mutation
Tumorigenesis
Elderly
Carcinogenesis
Cell aging
Carcinogens
Aging
Carnero, Amancio et al.
© The Author 2015. Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells that acquire a growth advantage over the remaining cell population through the acquisition of 'driver mutations' enabling a selective advantage in a particular micro-environment. Clonal selection is the driving force behind tumorigenesis and possesses three basic requirements: (i) effective competitive proliferation of the variant clone when compared with its neighboring cells, (ii) acquisition of an indefinite capacity for self-renewal, and (iii) establishment of sufficiently high levels of genetic and epigenetic variability to permit the emergence of rare variants. However, several questions regarding the process of clonal evolution remain. Which cellular processes initiate carcinogenesis in the first place? To what extent are environmental carcinogens responsible for the initiation of clonal evolution? What are the roles of genotoxic and non-genotoxic carcinogens in carcinogenesis?
Ministry of Education, Culture, Sports, Science, and Technology of Japan from Japan Science and Technology Agency and JST, CREST (to H.K.); triennial project grant (Strategic Award) from the National Centre for the Replacement, Refinement and Reduction of animals in research (NC.K500045.1 and G0800697 to H.Y.); ISCIII (Instituto de salud Carlos III) (FIS: PI12/01104 to M.L.); Spanish Ministry of Economy and Competitivity, Plan Nacional de I+D+I 2008-2011, Instituto de Salud Carlos III (Fis: PI12/00137, RTICC: RD12/0036/0028 to A. C.) co-funded by FEDER from Regional Development European Funds (European Union), Consejeria de Ciencia e Innovacion (CTS-6844 and CTS-1848 to A. C.) and Consejeria de Salud of the Junta de Andalucia (PI-0135-2010 and PI-0306-2012 to A. C.); National Institute of Environmental Health Sciences (ES016893 to J.P.W.), Maine Center for Toxicology and Environmental Health (J.P.W.); Fondazione Cariplo (2011-0370 to C.M.); United States National Institute of Health-National Institute of Environmental Health Sciences. Kuwait Institute for the Advancement of Sciences (2011-1302-06 to F. al-M.), Grant University Scheme (RUGs) Ministry Of Education Malaysia (04-02-12-2099RU to R.A.H.), Italian Ministry of University and Research (2009FZZ4XM_002 to A.A), the University of Florence (ex60%2012 to A.A.), US Public Health Service Grants (RO1 CA92306, RO1 CA92306-S1, RO1 CA113447 to R.R.), Department of Science and Technology, Government of India (SR/FT/LS-063/2008 to N.S.).
Peer Reviewed
2017-01-25T12:27:33Z
2017-01-25T12:27:33Z
2015-06-19
2017-01-25T12:27:33Z
artículo
http://purl.org/coar/resource_type/c_6501
e-issn: 1460-2180
issn: 0143-3334
Carcinogenesis 36(Suppl 1): S19-S37 (2015)
http://hdl.handle.net/10261/142998
10.1093/carcin/bgv029
http://dx.doi.org/10.13039/501100002241
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26106138
http://doi.org/10.1093/carcin/bgv029
Sí
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Oxford University Press