2024-03-29T07:12:34Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1264892020-05-28T13:37:28Zcom_10261_5063com_10261_5com_10261_34col_10261_5066col_10261_287
Fundamental aspects of the nucleic acid i-motif structures
Benabou, Sanae
Aviñó, Anna
González, Carlos
Eritja Casadellà, Ramón
Gargallo, Raimundo
Chemical stability
Nucleic acids
Oncogenic viruses
Base pairs
Building blockes
ph value
G-quadruplexes
promoter region
I-motif
In-vivo
Chemical modification
The i-motif structure is formed in cytosine-rich sequences, its building block being the cytosine·cytosine + base pair. This structure is particularly stable at pH values below physiological (∼7.4) and, because of that, it has not attracted as much biological interest as other non-canonical structures such as the G-quadruplex. Nowadays, the proposal of potential roles in vivo, as well as nanotechnological applications, has produced an increasing interest in its study. In this context, the present work provides an overall picture of the i-motif structure. Those aspects related to formation and stability, such as chemical modifications or the interaction with ligands, are discussed. Special attention has been made to the i-motif structures that could have a hypothetical role in vivo, such as those present near the promoter region of several oncogenes.
We acknowledge funding from the Spanish government (CTQ2012-38616-C02-02 and CTQ-2010-20541-C03). Sanae Benabou thanks the Spanish Ministerio de Economía y Competitividad for a PhD grant.
Peer reviewed
2015-12-04T07:46:11Z
2015-12-04T07:46:11Z
2014
artículo
http://purl.org/coar/resource_type/c_6501
RSC Advances 4: 26956-26980 (2014)
http://hdl.handle.net/10261/126489
10.1039/c4ra02129k
2046-2069
en
Postprint
http://doi.org/10.1039/c4ra02129k
Sí
open
Royal Society of Chemistry (UK)