2024-03-29T00:38:19Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1182112016-10-20T09:35:35Zcom_10261_128com_10261_1col_10261_381
A conserved transcriptional network regulates lamina development in the Drosophila visual system
Piñeiro, Cristina
Lopes, Carla S.
Casares, Fernando
Ministerio de Ciencia e Innovación (España)
Ministerio de Economía y Competitividad (España)
European Commission
The visual system of insects is a multilayered structure composed externally by the compound eye and internally by the three ganglia of the optic lobe: Lamina, medulla and the lobula complex. The differentiation of lamina neurons depends heavily on Hedgehog (Hh) signaling, which is delivered by the incoming photoreceptor axons, and occurs in a wave-like fashion. Despite the primary role of lamina neurons in visual perception, it is still unclear how these neurons are specified from neuroepithelial (NE) progenitors. Here we show that a homothorax (hth)-eyes absent (eya)-sine oculis (so)- dachshund (dac) gene regulatory cassette is involved in this specification. Lamina neurons differentiate from NE progenitors that express hth, eya and so. One of the first events in the differentiation of lamina neurons is the upregulation of dac expression in response to Hh signaling. We show that this dac upregulation, which marks the transition from NE progenitors into lamina precursors, also requires Eya/So, the expression of which is locked in by mutual feedback. dac expression is crucial for lamina differentiation because it ensures repression of hth, a negative regulator of single-minded, and thus dac allows further lamina neuron differentiation. Therefore, the specification of lamina neurons is controlled by coupling the cell-autonomous hth-eya-so-dac regulatory cassette to Hh signaling.
This work was funded by the Spanish Ministry for Science and Innovation (MICINN/MINECO) and Feder Funds through grants [BFU2012-34324] to F.C. C.P. was funded by a fellowship [FPI BES-2007-16473] from MICINN, and C.S.L. by the Juan de la Cierva Program (MICINN/MINECO).
Peer Reviewed
2015-07-21T15:17:56Z
2015-07-21T15:17:56Z
2014
2015-07-21T15:17:56Z
artículo
http://purl.org/coar/resource_type/c_6501
doi: 10.1242/dev.108670
issn: 1477-9129
Development 141(14): 2838-2847 (2014)
http://hdl.handle.net/10261/118211
10.1242/dev.108670
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
Sí
none
Company of Biologists