2024-03-28T10:09:00Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1124192021-12-28T16:16:25Zcom_10261_9676com_10261_8col_10261_9677
Earliest holozoan expansion of phosphotyrosine signaling
Suga, Hiroshi
Torruella, Guifré
Burger, Gertraud
Brown, Matthew W.
Ruiz-Trillo, Iñaki
European Research Council
Ministerio de Ciencia e Innovación (España)
European Commission
Tyrosine kinase
Ichthyosporeans Corallochytreans
Multicellularity
Evolution
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Phosphotyrosine (pTyr) signaling is involved in development and maintenance of metazoans' multicellular body through cell-to-cell communication. Tyrosine kinases (TKs), tyrosine phosphatases, and other proteins relaying the signal compose the cascade. Domain architectures of the pTyr signaling proteins are diverse in metazoans, reflecting their complex intercellular communication. Previous studies had shown that the metazoan-type TKs, as well as other pTyr signaling proteins, were already diversified in the common ancestor of metazoans, choanoflagellates, and filastereans (which are together included in the clade Holozoa) whereas they are absent in fungi and other nonholozoan lineages. However, the earliest-branching holozoans Ichthyosporea and Corallochytrea, as well as the two fungi-related amoebae Fonticula and Nuclearia, have not been studied. Here, we analyze the complete genome sequences of two ichthyosporeans and Fonticula, and RNAseq data of three additional ichthyosporeans, one corallochytrean, and Nuclearia. Both the ichthyosporean and corallochytrean genomes encode a large variety of receptor TKs (RTKs) and cytoplasmic TKs (CTKs), as well as other pTyr signaling components showing highly complex domain architectures. However, Nuclearia and Fonticula have no TK, and show much less diversity in other pTyr signaling components. The CTK repertoires of both Ichthyosporea and Corallochytrea are similar to those of Metazoa, Choanoflagellida, and Filasterea, but the RTK sets are totally different from each other. The complex pTyr signaling equipped with positive/negative feedback mechanism likely emerged already at an early stage of holozoan evolution, yet keeping a high evolutionary plasticity in extracellular signal reception until the co-option of the system for cell-to-cell communication in metazoans. © 2013 The Author 2013. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
This work was supported by the European Research Council Starting grant ERC-2007-StG-206883 to I.R.-T; Ministerio de Ciencia e Innovación grant BFU2008-02839/BMC to I.R.-T.; and the Marie Curie Intra-European Fellowship (MMEMA) within the 7th European Community Framework Programme to H.S.
Peer Reviewed
2015-03-16T11:47:33Z
2015-03-16T11:47:33Z
2014
2015-03-16T11:47:33Z
artículo
http://purl.org/coar/resource_type/c_6501
doi: 10.1093/molbev/mst241
e-issn: 1537-1719
issn: 0737-4038
Molecular Biology and Evolution 31(3): 517-528 (2014)
http://hdl.handle.net/10261/112419
10.1093/molbev/mst241
http://dx.doi.org/10.13039/501100000781
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100000780
24307687
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/206883
Publisher's version
http://dx.doi.org/10.1093/molbev/mst241
Sí
open
Oxford University Press