2024-03-28T23:52:41Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1001342021-12-28T16:38:39Zcom_10261_31891com_10261_2col_10261_31892
Long-term effect of an aqueous Fraxinus excelsior L. seed extract in spontaneously hypertensive rats
López-Carreras, Noemi
Fernández-Vallinas, Sandra
Miguel, Marta
Aleixandre, Amaya
This is an open access article distributed under the Creative Commons Attribution License.
The effect of long-term intake of different doses (20, 40, and 60 mg/kg/day) of a Fraxinus excelsior L. seed extract (FESE) on spontaneously hypertensive rats (SHR) was evaluated. Water was used as control and captopril (50 mg/kg/day) was used as positive control. Systolic blood pressure, body weight, and food and liquid intake were registered weekly in SHR. The antioxidant and vascular relaxing properties of FESE were also studied in these animals. The development of hypertension was attenuated in the groups treated with captopril or FESE. The antihypertensive effect was more accentuated in the captopril group than in the FESE groups, and it was paradoxically more accentuated in the groups treated with 20 mg/kg/day or 40 mg/kg/day of FESE than in the group treated with the highest dose of this extract. Body weight gain and food intake increased in the FESE groups. After removing the corresponding antihypertensive treatment, the arterial blood pressure and the body weight of the FESE treated animals returned to control values. In addition, FESE increased plasma antioxidant capacity and decreased plasma and liver malondialdehyde levels. Moreover, acetylcholine relaxation improved in the aorta rings from the FESE treated rats. © 2014 Noemi López-Carreras et al.
Peer Reviewed
2014-07-18T09:22:36Z
2014-07-18T09:22:36Z
2014
2014-07-18T09:22:37Z
artículo
http://purl.org/coar/resource_type/c_6501
doi: 10.1155/2014/565212
issn: 2090-0384
e-issn: 2090-0392
International Journal of Hypertension: 565212 (2014)
http://hdl.handle.net/10261/100134
10.1155/2014/565212
24696778
Publisher's version
http://dx.doi.org/10.1155/2014/565212
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open
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