2024-03-28T14:51:33Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/892942016-09-09T11:05:37Zcom_10261_118com_10261_6col_10261_497
Palacios Chaves, Leyre
Conde Álvarez, Raquel
Zúñiga Ripa, Amaia
Grilló, María Jesús
Iriarte, Maite
Moriyón, Ignacio
Gutsmann, Thomas
2014-01-13T08:26:31Z
2014-01-13T08:26:31Z
2012-09
Annual Meeting of the German Biophysical Society (2012)
http://hdl.handle.net/10261/89294
The members of the genus Brucella are α-2 Proteobacteria that cause brucellosis, an
important zoonosis. These bacteria trigger only low proinflammatory responses during early infection
that allows them to reach sheltered intracellular niches before effective immunity activation.
The outer membranes (OM) of brucellae are of critical importance in this strategy. The OM of B.
abortus is unusually resistant to antimicrobial peptides (AMPs). Brucella lipopolysaccharide (LPS) is
implicated in this property and there is evidence that other lipids (such as phosphatidylcholine) also
contribute. Furthermore, these bacteria have acyl chains of average number of carbon units which
leads an increase in hydrophobicity, proposed as a biophysical factor underlining AMPs resistance.
eng
openAccess
Relation between the lipid composition of Brucella membrane and the resistance to cationic peptides
póster de congreso