2024-03-29T11:00:22Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/830152022-01-31T11:06:30Zcom_10261_28457com_10261_3col_10261_28462
Hazeri, Nourallah
García-Granda, Santiago
Torre-Fernández, Laura
2013-09-30T11:22:36Z
2013-09-30T11:22:36Z
2013-01
Heteroatom Chemistry 24(1): 58-65 (2013)
1042-7163
http://hdl.handle.net/10261/83015
10.1002/hc.21063
1098-1071
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
A three-component synthesis of α-aminophosphonate is described from a reaction between aldehydes, 2-aminobenzothiazole, and triethyl phosphite in the presence of InCl3 as a catalyst under solvent-free conditions for the generation of the particular α-aminophosphonates. These products have two potentially biologically active parts, aminophosphonate and benzothiazole. This method offers advantages such as short reaction times, good yields, solvent-free conditions, and easy workup with the green aspects by avoiding toxic catalysts and solvents. The crystal structure of 4b has been determined by X-ray crystallography. This compound crystallizes in the monoclinic space group C2/c with cell parameters a = 21.9285(5) Å, b = 10.3221(2) Å, c = 18.5979(5) Å, β = 108.759(3)°, V = 3985.99(18) Å3, Dcalc = 1.301 mg m−3, and Z = 8. The final R value is 0.0501 for 3741 reflections.
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Synthesis and crystal structure study of diethyl aryl(benzo[d]thiazol-2-ylamino)methyl phosphonates
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