2024-03-28T12:18:15Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/815242021-10-27T07:10:06Zcom_10261_22com_10261_1col_10261_275
Pacheco-Torres, Jesús
Pérez-Mayoral, Elena
Soriano, Elena
López-Larrubia, Pilar
Ouari, Olivier
Cerdán, Sebastián
Ballesteros, Paloma
2013-09-05T11:29:21Z
2013-09-05T11:29:21Z
2006
Synthesis 22: 3859-3864 (2006)
http://hdl.handle.net/10261/81524
10.1055/s-2006-950320
http://dx.doi.org/10.13039/100012818
We report an easy and efficient synthetic approach to the first series of (nitroimidazolyl)succinic esters and diacids involving the Michael-type addition of the nitroimidazole to the α,β-unsaturated ester. Voltammetric measurements revealed similar redox potentials to those of previous nitroimidazoles used in hypoxia detection. Theoretical calculations were implemented to understand the mechanism of the addition. © Georg Thieme Verlag Stuttgart.
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A convenient and efficient synthesis of the first (nitroimidazolyl)succinic esters and their diacids
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