2024-03-28T12:51:48Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/444052019-03-04T08:29:14Zcom_10261_81com_10261_5col_10261_334
Dardonville, Christophe
Rozas, Isabel
Goya, Pilar
Girón, Rocío
Goicoechea, Carlos
Martín, M. Isabel
2012-01-18T10:13:25Z
2012-01-18T10:13:25Z
2003-02-03
Bioorganic & Medicinal Chemistry 11: 1283–1291 (2003)
0968-0896
http://hdl.handle.net/10261/44405
10.1016/S0968-0896(02)00637-5
In the present paper, we wish to report the synthesis and antinociceptive activity of a series of new azaalkane bis(2-
aminoimidazolinium) compounds from which, N,N0-di(4,5-dihydro-1H-imidazol-2-yl)-3-aza-1,6-hexanediamine 2a has shown the
best analgesic properties in vivo in two different assays (i.e., acetic acid-induced writhing test and hot-plate test in mice), as well as
oral bioavailability
eng
closedAccess
Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds
artículo