2024-03-29T07:14:23Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/366162016-03-10T12:46:57Zcom_10261_38com_10261_5col_10261_291
Brumshtein, Boris
Aguilar Moncayo, Matilde
García Moreno, María Isabel
Ortiz-Mellet, Carmen
García-Fernández, José Manuel
Silman, Israel
Shaaltiel, Yoseph
Aviezer, David
Sussman, Joel L.
Futerman, Anthony H.
2009-05-13
ChemBioChem 10(9): 1480-1485 (2009)
1429-4227
10261/36616
10.1002/cbic.200900142
1439-7633
6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin, a reducing analogue of N-nonyl-1-deoxynojirimycin, proved to be a potent and very selective inhibitor of β-glucosidases, including human acid β-glucosidase. Structural studies of the enzyme–inhibitor complex showed a binding mode in which the anomeric hydroxy group is accommodated in the “wrong” α configuration.
eng
closedAccess
Acid beta-glucosidase
Gaucher disease
Guanidine
Iminosugars
Inhibitors
Nojirimycin
6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β-Glucosidase
artículo