2024-03-28T14:35:24Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/235562016-02-16T06:39:38Zcom_10261_54com_10261_1col_10261_307
Ceci, María Laura
López-Mascaraque, Laura
Carlos, Juan A. de
2010-04-27T08:57:30Z
2010-04-27T08:57:30Z
2010-04-27T08:57:30Z
http://hdl.handle.net/10261/23556
10.1093/cercor/bhp305
During cerebral cortex development, different cell populations
migrate tangentially through the preplate, traveling from their site
of origin toward their final positions. One of the earliest populations
formed, the Cajal--Retzius (C-R) cells, is mainly generated in different
cortical hem (CH) domains, and they migrate along established and
parallel routes to cover the whole cortical mantle. In this study, we
present evidence that the phenotype of --Retzius cells, as well as
some of their migratory characteristics, is specified in the area
where the cells are generated. Nevertheless, when implanted
ectopically, these cells can follow new migratory routes, indicating
that locally provided genetic cues along the migratory path
nonautonomously influence the position of these cells emanating
from different portions of the CH. This was witnessed by performing
CH implants of tissue expressing fluorescent tracers in live whole
embryos. In the same way, tracer injections into the hem of Small
eye mutant mice were particularly informative since the lack of Pax6
affects some guidance factors in the migratory environment. As
a result, in these animals, the C-R cell population is disorganized, and
it forms 1 day late, showing certain differences in gene expression
that might help explain these disruptions.
eng
openAccess
Culture
development
Pax6
embryo
mouse
tangential
The Influence of the Environment on Cajal--Retzius Cell Migration
artículo