2024-03-29T10:33:26Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2173292021-12-28T15:55:38Zcom_10261_108com_10261_8col_10261_361
Hodžić, Adnan
Mateos-Hernández, Lourdes
Leschnik, Michael
Alberdi, Pilar
Rego, Ryan O. M.
Contreras, Marinela
Villar, Margarita
Fuente, José de la
Cabezas-Cruz, Alejandro
Gerhard Duscher, Georg
2020-08-04T07:38:49Z
2020-08-04T07:38:49Z
2019
Vaccines 7(3): 114 (2019)
2076-393X
http://hdl.handle.net/10261/217329
10.3390/vaccines7030114
http://dx.doi.org/10.13039/501100007480
http://dx.doi.org/10.13039/501100011698
31540167
Due to the functional inactivation of the gene encoding for the enzyme that is involved in the oligosaccharide galactose-α-1,3-galactose (α-Gal) synthesis, humans and Old-World primates are able to produce a large amount of antibodies against the glycan epitope. Apart from being involved in the hyperacute organ rejection in humans, anti-α-Gal antibodies have shown a protective effect against some pathogenic agents and an implication in the recently recognized tick-induced mammalian meat allergy. Conversely, non-primate mammals, including dogs, have the ability to synthetize α-Gal and, thus, their immune system is not expected to naturally generate the antibodies toward this self-antigen molecule. However, in the current study, we detected specific IgG, IgM, and IgE antibodies to α-Gal in sera of clinically healthy dogs by an indirect enzyme-linked immunosorbent assay (ELISA) for the first time. Furthermore, in a tick infestation experiment, we showed that bites of Ixodes ricinus induce the immune response to α-Gal in dogs and that the resulting antibodies (IgM) might be protective against Anaplasma phagocytophilum. These findings may help lead to a better understanding of the underlying mechanisms involved in mammalian meat allergy and tick-host-pathogen interactions, but they also open up the question about the possibility that dogs could develop an allergy to mammalian meat after tick bites, similar to that in humans.
eng
https://creativecommons.org/licenses/by/4.0/
openAccess
α-Gal
Immune response
Dog
Tick bite
Ixodes ricinus
Pathogens
Tick bites induce anti-α-Gal antibodies in dogs
artículo