2024-03-28T15:57:04Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1775412021-10-22T12:27:00Zcom_10261_46com_10261_3col_10261_299
Ardizzone, Antonio
Blasi, Davide
Vona, Danilo
Rosspeintner, Arnulf
Punzi, Angela
Altamura, Emiliano
Grimaldi, Natascia
Sala Vergés, Santiago
Vauthey, Eric
Farinola, Gianluca M.
Ratera, Immaculada
Ventosa, Nora
Veciana, Jaume
2019-03-08T10:18:06Z
2019-03-08T10:18:06Z
2018-08-06
Chemistry - a European Journal 24(44): 11386-11392 (2018)
0947-6539
http://hdl.handle.net/10261/177541
http://dx.doi.org/10.13039/501100008737
http://dx.doi.org/10.13039/501100003407
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100002809
http://dx.doi.org/10.13039/501100005053
http://dx.doi.org/10.13039/501100006389
Diketopyrrolopyrroles (DPPs) have recently attracted much interest as very bright and photostable red‐emitting molecules. However, their tendency to form nonfluorescent aggregates in water through the aggregation‐caused quenching (ACQ) effect is a major issue that limits their application under the microscope. Herein, two DPP molecules have been incorporated into the membrane of highly stable and water‐soluble quatsomes (QS; nanovesicles composed of surfactants and sterols), which allow their nanostructuration in water and, at the same time, limits the ACQ effect. The obtained fluorescent organic nanoparticles showed superior structural homogeneity, along with long‐term colloidal and optical stability. A thorough one‐ (1P) and two‐photon (2P) fluorescence characterization revealed the promising photophysical features of these fluorescent nanovesicles, which showed a high 1P and 2P brightness. Finally, the fluorescent QSs were used for the in vitro bioimaging of Saos‐2 osteosarcoma cell lines; this demonstrates their potential as nanomaterials for bioimaging applications.
eng
openAccess
Aggregation
Fluorescence
Imaging agents
Nanoparticles
Vesicles
Highly Stable and Red‐Emitting Nanovesicles Incorporating Lipophilic Diketopyrrolopyrroles for Cell Imaging
artículo