2024-03-28T23:30:56Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1744562021-12-27T16:17:35Zcom_10261_41com_10261_1col_10261_294
Olivares-Castiñeira, Ivette
Llimargas, Marta
2019-01-21T15:51:21Z
2019-01-21T15:51:21Z
2017-07-05
PLoS Genetics 13(7): e1006882 (2017)
1553-7390
http://hdl.handle.net/10261/174456
10.1371/journal.pgen.1006882
1553-7404
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100002809
28678789
Development is governed by a few conserved signalling pathways. Amongst them, the
EGFR pathway is used reiteratively for organ and tissue formation, and when dysregulated
can lead to cancer and metastasis. Given its relevance, identifying its downstream molecular machinery and understanding how it instructs cellular changes is crucial. Here we
approach this issue in the respiratory system of Drosophila. We identify a new role for
EGFR restricting the elongation of the tracheal Dorsal Trunk. We find that EGFR regulates
the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously
known to control tube length. EGFR regulates the organisation of endosomes in which Crb
and Serp proteins are loaded. Our results are consistent with a role of EGFR in regulating
Retromer/WASH recycling routes. Furthermore, we provide new insights into Crb trafficking
and recycling during organ formation. Our work connects cell signalling, trafficking mechanisms and morphogenesis and suggests that the regulation of cargo trafficking can be a
general outcome of EGFR activation
eng
https://creativecommons.org/licenses/by/4.0/
openAccess
EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation
artÃculo