2024-03-29T08:29:25Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1505552019-11-19T09:14:50Zcom_10261_80com_10261_1com_10261_103col_10261_333col_10261_356
Briones-Moreno, Asier
Hernández-García, Jorge
Vargas-Chávez, Carlos
Romero-Campero, Francisco J.
Romero, José M.
Valverde, Federico
Blázquez, Miguel Ángel
2017-05-29T08:57:31Z
2017-05-29T08:57:31Z
2017-04-25
Frontiers in Plant Science 8: 626 (2017)
http://hdl.handle.net/10261/150555
10.3389/fpls.2017.00626
1664-462X
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100003176
28487716
DELLA proteins are transcriptional regulators present in all land plants which have
been shown to modulate the activity of over 100 transcription factors in Arabidopsis,
involved in multiple physiological and developmental processes. It has been proposed
that DELLAs transduce environmental information to pre-wired transcriptional circuits
because their stability is regulated by gibberellins (GAs), whose homeostasis largely
depends on environmental signals. The ability of GAs to promote DELLA degradation
coincides with the origin of vascular plants, but the presence of DELLAs in other
land plants poses at least two questions: what regulatory properties have DELLAs
provided to the behavior of transcriptional networks in land plants, and how has the
recruitment of DELLAs by GA signaling affected this regulation. To address these issues,
we have constructed gene co-expression networks of four different organisms within
the green lineage with different properties regarding DELLAs: Arabidopsis thaliana and
Solanum lycopersicum (both with GA-regulated DELLA proteins), Physcomitrella patens
(with GA-independent DELLA proteins) and Chlamydomonas reinhardtii (a green alga
without DELLA), and we have examined the relative evolution of the subnetworks
containing the potential DELLA-dependent transcriptomes. Network analysis indicates
a relative increase in parameters associated with the degree of interconnectivity in the
DELLA-associated subnetworks of land plants, with a stronger effect in species with
GA-regulated DELLA proteins. These results suggest that DELLAs may have played
a role in the coordination of multiple transcriptional programs along evolution, and
the function of DELLAs as regulatory ‘hubs’ became further consolidated after their
recruitment by GA signaling in higher plants
eng
http://creativecommons.org/licenses/by/4.0/
openAccess
Gene co-expression networks
Integrative molecular systems biology
Evo-devo
Transcriptional regulation
Plant signaling
Evolutionary Analysis of DELLA-Associated Transcriptional Networks
artículo