2024-03-28T15:14:47Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1488132017-07-05T12:15:39Zcom_10261_31com_10261_3col_10261_410
Matteis, Laura de
García-Embid, Sonia
Serrano-Sevilla, Inés
Fuente, Jesús M. de la
2017-04-25T10:48:14Z
2017-04-25T10:48:14Z
2016
IMI Translocation (2016)
http://hdl.handle.net/10261/148813
The combination of nanoemulsion method and chitosan coating presented in this
work has been proved to be a promising strategy to obtain a versatile multi-pocket
nanocarrier. The use of antibiotics produces important side effects, thus reducing the dose of administration and targeting the infection sites are issues of important concern.
Nanotechnology represents an important tool to improve the residence and blood
circulation time of the delivered drugs so allowing the reduction of the dose and
possibly the side effects. In the past few decades, many kinds of nanocarriers have been developed for delivery and targeting of therapeutic or diagnostic agents for medical treatments, thanks to some important advantages that they offer depending on their physicochemical properties. Different antibiotics active both against MRSA (Methicillin-resistant Staphylococcus aureus) and MRTB (Multi-resistant Mycobacterium tuberculosis) have been successfully encapsulated in nanoemulsion-based chitosan nanocapsules. In particular, bedaquiline, amikacin, active against Mycobacterium tuberculosis, and daptomycin, against Staphylococcus aureus. The encapsulation of the selected antibiotics is reported, in terms of optimization of the drug loading and encapsulation efficiency of the process. The systems obtained have been fully characterized and their antimicrobial effect has been tested, proving the maintenance of the drug activity once the antibiotic is encapsulated.
eng
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Nanoemulsion-based chitosan nanocapsules as antibiotic delivery system
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