2024-03-28T09:03:43Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/126512023-01-10T12:29:41Zcom_10261_133com_10261_1col_10261_386
Little, Graham E.
López-Bendito, Guillermina
Rünker, Annette E.
García Lillo, Noelia
Piñón, Maria C.
Chédotal, Alain
Molnár, Zoltán
Mitchell, Kevin J.
2009-04-28T17:02:54Z
2009-04-28T17:02:54Z
2009-04-28
PloS Biology 7(4): e1000098
1544-9173
http://hdl.handle.net/10261/12651
10.1371/journal.pbio.1000098
1545-7885
19402755
The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model to test current ideas on the interactions between subcortical and cortical guidance mechanisms and cortical regionalization. In these mutants, axons from the dorsal lateral geniculate nucleus (dLGN) are misrouted in the ventral telencephalon. This leads to invasion of presumptive visual cortex by somatosensory thalamic axons at embryonic stages. Remarkably, the misrouted dLGN axons are able to find their way to the visual cortex via alternate routes at postnatal stages and reestablish a normal pattern of thalamocortical connectivity. These findings emphasize the importance and specificity of cortical cues in establishing thalamocortical connectivity and the spectacular capacity of the early postnatal cortex for remapping initial sensory representations.
eng
openAccess
Specificity and Plasticity of Thalamocortical Connections in Sema6A Mutant Mice
artículo