2024-03-29T05:32:47Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1246792020-08-12T12:03:31Zcom_10261_41com_10261_1col_10261_294
Vizcaíno, Carolina
Mansilla, Sylvia
Portugal, José
2015-11-09T11:03:53Z
2015-11-09T11:03:53Z
2015-06-29
Pharmacology and Therapeutics 152: 111124 (2015)
1879016X
http://hdl.handle.net/10261/124679
10.1016/j.pharmthera.2015.05.008
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003339
© 2015 Elsevier Ltd. All rights reserved. Sp1 (specificity protein 1) is a wellknown member of a family of
transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and
carcinogenesis. Sp1 activates the transcription of many cellular genes that contain putative CG-rich Sp-binding sites in their promoters. Sp1 and Sp3 proteins bind to similar, if not the same, DNA tracts and compete for binding, thus they can enhance or repress gene expression. Evidences exist that the Sp-family
of proteins regulates the expression of genes that play pivotal roles in cell proliferation and metastasis of various tumors. In patients with a variety of cancers, high levels of Sp1 protein are considered a negative prognostic factor. A plethora of compounds can interfere with the trans-activating activities of Sp1 and other Sp proteins on gene expression. Several pathways are involved in the down-regulation of Sp proteins by compounds with different mechanisms of action, which include not only the direct interference with the binding of Sp proteins to their putative DNA binding sites, but also promoting the degradation of Sp protein factors. Down-regulation of Sp transcription factors and Sp1-regulated genes is drug-dependent and it is determined by the cell context. The acknowledgment that several of those compounds are safe enough might accelerate their introduction into clinical usage in patients with tumors that over-express Sp1
eng
http://creativecommons.org/licenses/by-nc-nd/4.0/
openAccess
Anticancer drugs
Prognosis
Sp1
Sp3
Transcription factors
Targeted therapy
Sp1 transcription factor: A long-standing target in cancer chemotherapy
artículo