2024-03-29T14:20:47Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1132802021-12-28T15:38:34Zcom_10261_9676com_10261_8col_10261_9677
Hartasánchez Frenk, Diego
Vallès-Codina, Oriol
Brasó-Vives, Marina
Navarro, Arcadi
2015-04-06T10:55:26Z
2015-04-06T10:55:26Z
2014-08-01
G3 4(8): 1479-1489 (2014)
http://hdl.handle.net/10261/113280
10.1534/g3.114.012435
http://dx.doi.org/10.13039/501100003141
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100000780
24906640
Interlocus gene conversion is a major evolutionary force that drives the concerted evolution of duplicated genomic regions. Theoretical models successfully have addressed the effects of interlocus gene conversion and the importance of crossover in the evolutionary fate of gene families and duplications but have not considered complex recombination scenarios, such as the presence of hotspots. To study the interplay between interlocus gene conversion and crossover, we have developed a forward-time simulator that allows the exploration of a wide range of interlocus gene conversion rates under different crossover models. Using it, we have analyzed patterns of nucleotide variation and linkage disequilibrium within and between duplicate regions, focusing on a neutral scenario with constant population size and validating our results with the existing theoretical models. We show that the interaction of gene conversion and crossover is nontrivial and that the location of crossover junctions is a fundamental determinant of levels of variation and linkage disequilibrium in duplicated regions. We also show that if crossover activity between duplications is strong enough, recurrent interlocus gene conversion events can break linkage disequilibrium within duplicates. Given the complex nature of interlocus gene conversion and crossover, we provide a framework to explore their interplay to help increase knowledge on molecular evolution within segmental duplications under more complex scenarios, such as demographic changes or natural selection. © 2014 Hartasánchez et al.
eng
http://creativecommons.org/licenses/by/3.0/
openAccess
Forward simulations
Recombination hotspots
Concerted evolution
Increased variation
Linkage disequilibrium
Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario
artículo