2024-03-29T15:24:44Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1112652018-09-17T12:22:56Zcom_10261_9676com_10261_8col_10261_9677
Invergo, Brandon M.
Dell’Orco, Daniele
Montanucci, Ludovica
Koch, Karl-Wilhelm
Bertranpetit, Jaume
2015-02-25T13:53:47Z
2015-02-25T13:53:47Z
2014-03
Molecular BioSystems 10: 1481-1489 (2014)
http://hdl.handle.net/10261/111265
10.1039/c3mb70584f
http://dx.doi.org/10.13039/501100006280
http://dx.doi.org/10.13039/501100002809
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100003407
Vertebrate visual phototransduction is perhaps the most well-studied G-protein signaling pathway. A wealth of available biochemical and electrophysiological data has resulted in a rich history of mathematical modeling of the system. However, while the most comprehensive models have relied upon amphibian biochemical and electrophysiological data, modern research typically employs mammalian species, particularly mice, which exhibit significantly faster signaling dynamics. In this work, we present an adaptation of a previously published, comprehensive model of amphibian phototransduction that can produce quantitatively accurate simulations of the murine photoresponse. We demonstrate the ability of the model to predict responses to a wide range of stimuli and under a variety of mutant conditions. Finally, we employ the model to highlight a likely unknown mechanism related to the interaction between rhodopsin and rhodopsin kinase. © 2014 the Partner Organisations.
spa
http://creativecommons.org/licenses/by-nc/3.0/
openAccess
A comprehensive model of the phototransduction cascade in mouse rod cells
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