2024-03-29T01:01:14Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/881482020-08-12T13:37:26Zcom_10261_81com_10261_5col_10261_334
DIGITAL.CSIC
author
Castro, Ana
author
Abasolo, M. Inés
author
Gil, Carmen
author
Segarra, Victor
author
Martínez, Ana
2013-12-03T14:33:08Z
2013-12-03T14:33:08Z
2001
European Journal of Medicinal Chemistry 36: 333- 338 (2001)
http://hdl.handle.net/10261/88148
10.1016/S0223-5234(01)01227-2
A CoMFA study of benzo- and benzothienothiadiazines derivatives as phosphodiesterase 7 inhibitors has been carried out in order to determine the factors required for the activity of these compounds and also for the selectivity versus other phosphodiesterase isoenzymes. This methodology is employed to gain clues on the design of new fused thiadiazines with improved activity and selectivity on phosphodiesterase 7. Using the information achieved from the three CoMFA models, new structures have been designed in silico and their inhibitory activity on phosphodiesterase 7 was predicted. © 2001 Éditions scientifiques et médicales Elsevier SAS.
eng
closedAccess
CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-a]thiadiazine 2,2-dioxides: Clues for the design of phosphodiesterase 7 inhibitors
artículo
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URL
https://digital.csic.es/bitstream/10261/88148/1/accesoRestringido.pdf
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accesoRestringido.pdf
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https://digital.csic.es/bitstream/10261/88148/5/accesoRestringido.pdf.txt
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accesoRestringido.pdf.txt