2024-03-28T07:12:14Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/674112018-08-07T10:10:45Zcom_10261_103com_10261_1col_10261_356
DIGITAL.CSIC
author
Lalic, Jasna
author
Elena, Santiago F.
author
Elena, Santiago F.
2013-02-26T12:42:52Z
2013-02-26T12:42:52Z
2012-04
Heredity 109/2: 71-77 (2012)
0018-067X
http://hdl.handle.net/10261/67411
22491062
How epistatic interactions between mutations determine the genetic architecture of fitness is of central importance in evolution. The study of epistasis is particularly interesting for RNA viruses because of their genomic compactness, lack of genetic redundancy, and apparent low complexity. Moreover, interactions between mutations in viral genomes determine traits such as resistance to antiviral drugs, virulence and host range. In this study we generated 53 Tobacco etch potyvirus genotypes carrying pairs of single-nucleotide substitutions and measured their separated and combined deleterious fitness effects. We found that up to 38% of pairs had significant epistasis for fitness, including both positive and negative deviations from the null hypothesis of multiplicative effects. Interestingly, the sign of epistasis was correlated with viral protein-protein interactions in a model network, being predominantly positive between linked pairs of proteins and negative between unlinked ones. Furthermore, 55% of significant interactions were cases of reciprocal sign epistasis (RSE), indicating that adaptive landscapes for RNA viruses maybe highly rugged. Finally, we found that the magnitude of epistasis correlated negatively with the average effect of mutations. Overall, our results are in good agreement to those previously reported for other viruses and further consolidate the view that positive epistasis is the norm for small and compact genomes that lack genetic robustness.
eng
openAccess
Tobacco
Antagonistic epistasis
Compensatory mutations
Antibiotic resistance
Secondary structure
Genomic complexity
Fitness landscapes
Genetic constraint
Escherichia-Coli
Evolution
Magnitude and sign epistasis among deleterious mutations in a positive-sense plant RNA virus
artÃculo
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URL
https://digital.csic.es/bitstream/10261/67411/1/Lalic%20Elena%20Heredity.pdf
File
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application/pdf
Lalic Elena Heredity.pdf
URL
https://digital.csic.es/bitstream/10261/67411/4/Lalic%20Elena%20Heredity.pdf.txt
File
MD5
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text/plain
Lalic Elena Heredity.pdf.txt